Hiscan VM Pro是一款快速靈活的活體顯微CT，主要用于動(dòng)物實(shí)驗(yàn)。其所用的錐束X射線可以看到樣本的內(nèi)部結(jié)構(gòu)，最高分辨率可達(dá)18μm。可做小動(dòng)物全身掃描，如小鼠、大鼠等。同時(shí)，可以掃描所選擇的感興趣區(qū)域，例如小鼠和大鼠的頭部、脊椎、前肢 、后肢等。根據(jù)樣本尺寸不同配以不同尺寸的掃描床，獨(dú)特設(shè)計(jì)的掃描床可以防止小動(dòng)物逃逸落進(jìn)機(jī)器內(nèi)。

　　Hiscan VM Pro配有高精度自適應(yīng)呼吸門(mén)控，可根據(jù)呼吸周期的變化動(dòng)態(tài)調(diào)整圖像采集速度，有效減少呼吸帶來(lái)的胸廓運(yùn)動(dòng)偽影。防護(hù)機(jī)殼配有麻醉氣體傳輸接口以及多種生理監(jiān)控設(shè)備接口。X射線機(jī)殼防護(hù)安全可靠，操作人員無(wú)需額外防護(hù)。同時(shí)配有安全連鎖裝置，倉(cāng)門(mén)打開(kāi)時(shí)自動(dòng)關(guān)閉X射線，避免誤操作，保證操作人員安全。

       廣泛應(yīng)用于骨骼疾病、腫瘤疾病、心血管疾病、炎癥疾病、代謝疾病、免疫學(xué)、藥效評(píng)價(jià)、生物材料等學(xué)科的臨床前研究。

　? 高精度呼吸門(mén)控

　　通過(guò)高精度呼吸門(mén)控采集呼吸信號(hào)，根據(jù)呼吸信號(hào)波形進(jìn)行圖像采集獲得同一呼吸相位的圖像，從而消除呼吸運(yùn)動(dòng)帶來(lái)的偽影，獲得清晰的重建圖像。同時(shí)具有自適應(yīng)性，根據(jù)不同小鼠的呼吸頻率自動(dòng)調(diào)整圖像采集速度，智能掃描。

　? 精密設(shè)計(jì)掃描床

　　經(jīng)過(guò)精密設(shè)計(jì)的掃描床，操作方便，小動(dòng)物放置在前部透明掃描倉(cāng)內(nèi)，配有攝像頭監(jiān)控小動(dòng)物呼吸;同時(shí)配有麻醉氣體接口，保證小鼠呼吸穩(wěn)定;另外還配有造影劑持續(xù)注射接口，可持續(xù)造影，用于灌注成像。

   ? 多模態(tài)圖像融合技術(shù)

　　為多模態(tài)圖像融合設(shè)計(jì)獨(dú)特配準(zhǔn)裝置，掃描床上有特定標(biāo)記位點(diǎn)，在多種設(shè)備上均可成像，根據(jù)這些特定標(biāo)記位點(diǎn)進(jìn)行圖像配準(zhǔn)融合。

　? GPU加速快速分層重建

　　采用經(jīng)過(guò)優(yōu)化的快速分層重建算法，并使用GPU進(jìn)行硬件加速，重建速度提高到掃描結(jié)束重建同時(shí)完成。

參考文獻(xiàn)：

1、Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization. Yingqian Wang, Jie Wang, Yufeng Zhang, Quan Yuan et al. Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University. Nature Communications. 2019,10,2829

2、GSH-Depleted PtCu3 Nanocages for Chemodynamic- Enhanced Sonodynamic Cancer Therapy. Xiaoyan Zhong, Liang Cheng, Yong’an Tang, Zhuang Liu, Xiangliang Yang, et al. National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology. Institute of Functional Nano and Soft Materials (FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University. Advanced Functional Materials, DOI: 10.1002/adfm.201907954.

3、CT/Bioluminescence Dual-Modal Imaging Tracking of Mesenchymal Stem Cells in Pulmonary Fibrosis. Hongying Bao, Jie Huang, Zhijun Zhang et al. CAS Key Laboratory of Nano-BioInterface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences. Small. DOI:10.1002/smll.201904314

4、Long-term in vivo CT tracking of mesenchymal stem cells labeled with Au@BSA@PLL nanotracers. Xinyu Ning, Jie Huang, Zhijun Zhang et al. CAS Key Laboratory of Nano-BioInterface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences. Nanoscale. DOI:10.1039/c9nr5637h

5、 Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ /BMP signaling in triple-negative breast cancer. Lei Di, Li-Juan Liu, Rong Fu, Yong-Xian Cheng, Zhao-Qiu Wu, et al. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center. Journal of Experimental & Cancer Research. 2019,38,134

6、PEGylated hollow gold nanoparticles for combined X-ray radiation and photothermal therapy in vitro and enhanced CT imaging in vivo. Ru Wang, Yan Shen, et al. Department of Pharmaceutics, China Pharmaceutical University. School of Ophthalmology&Optometry, EyeHospital, School of Biomedical Engineering, Wenzhou Medical University. Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences. Department of Chemical Engineering Northeastern University, Boston. Department of Radiology, The First Affiliated Hospita lof Nanjing Medical University. Nanomedicine: Nanothechnology, Biology, and Medicine . 2019,16,195-205

7、Transplanted Endothelial Progenitor Cells Improve Ischemia Muscle Regeneration in Mice by Diffusion Tensor MR Imaging. Xin-Gui Peng, Shenghong Ju, Judy R. James, et al. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, southeast University. Department of Radiology, University of Mississippi Medical Center. Stem Cells International 2016, 3641401

8、The Role of Metal Nanoparticles in In?uencing Arbuscular Mycorrhizal Fungi E?ectson Plant Growth. Youzhi Feng, Shiying He, Ge Dong, Xiangui Lin et al. State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences. Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences. School of Biological Science and Medical Engineering, Southeast University. Environ. Sci. Technol. 2013, 47, 9496-9504

9、Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Cuiping Yang, Jun Dou, Ning Gu, et al. Department of Pathogenic Biology and Immunology, School of Medicine & Collaborative Innovation Center of Suzhou NanoScience and Technology, Southeast University. School of Biological Science & Medical Engineering & Collaborative Innovation Center of Suzhou NanoScience and Technology, Southeast University. ONCOTARGET . 2015,6(29),27714-27724

10、CT/fluorescence dual-modal nanoemulsion platform for investigating atherosclerotic plaques. Jiali Ding, Ning Gu, Ge Dong,Yu Zhang, et al. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices. School of Biological Science and Medical Engineering, Southeast University. Department of Radiation, The First Af?liated Hospital of Nanjing Medical University. Department of Cardiology, Xuzhou Medical College Second Af?liated Hospital. Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Medical School, SoutheastUniversity. BIOMATERIALS. 2013,34(1), 209-216

11、Anti-ABCG2 monoclonal antibody in combination with paclitaxel nanoparticles against cancer stem-like cell activity in multiple myeloma. Cuiping Yang, Jun Dou, et al. Department of Pathogenic Biology and Immunology Medical School, Southeast University . NANOMEDICINE. 2014,9(1), 45-60

12、Single-Irradiation Simultaneous Dual-Modal Bioimaging Using Nanostructure Scintillators as Single Contrast Agent. Qiang Ju, et al. Advanced Healthcare Materials. 2019, 1801324

13、A novel calibration method incorporating nonlinear optimization and ball‐bearing markers for cone-beam CT with a parameterized trajectory. Guang Li, Shouhua Luo, Ge Wang, Ning Gu, et al. Department of Biomedical Engineering, Southeast University. Department of Biomedical Engineering, Rensselaer Polytechnic Institute.Department of Bioengineering and Electrical Engineering, StanfordUniversity. Med Phys. 2019, 46(1):152-164.

14、Interior tomography in microscopic CT with image reconstruction constrained by full field of view scan at low spatial resolution. Shouhua Luo ,Tao Shen, Guang Li, Xiangyang Tang, et al. Department of Biomedical Engineering, Southeast University. Department of Radiology and Imaging Sciences, Emory University School of Medicine. Physics in Medicine & Biology, 2018, 63(7).

15、Geometric Calibration Based on a Simple Phantom for Multi-Lens Microscopic CT. Shouhua Luo, Haitao Xu, Liang Zheng， Guang Li， et al. Department of Biomedical Engineering, Southeast University. International Journal of Computational Methods, 2018, 1842015.

16、An Epipolar Based Algorithm for Respiratory Signal Extraction of Small Animal CT. Shuang Luo, Shouhua Luo. Department of Biomedical Engineering, Southeast University. Sensing & Imaging, 2018, 19(1):4

17、A fast beam hardening correction method incorporated in a filtered back-projection based MAP algorithm. Shouhua Luo, Huazhen Wu, Guang Li, Ning Gu, et al. Southeast University. Phys. Med. Biol. 2017,62, 1810–1830

18、Automated image registration for stand-alone micro-PET and micro-CT. Jing Yang, Guang Li, Shouhua Luo, et al. School of Biological Science and Medical Engineering, Southeast University. Journal of Nanoscience and Nanotechnology, 2016,16 (7), 6903-6909

19、A method of extending the depth of focus of the high-resolution X-ray imaging system employing optical lens and scintillator: a phantom study. Guang Li, Shouhua Luo, Yulin Yan, Ning Gu. School of Biological Science and Medical Engineering, Southeast University. BioMedical Engineering OnLine, 2015,14(1)

20、Light field rendering of scintillator for X-ray imaging. Xiaolong Wang, Shouhua Luo, Guang Li, Jing Yang. School of Biological Science and Medical Engineering, Southeast University Acta Photonica Sinica. 2013, 42(12),1528-1533

用戶名單：

南京鼓樓醫(yī)院 醫(yī)學(xué)影像科

華東師范大學(xué) 生命科學(xué)學(xué)院

江蘇省生物材料與器件重點(diǎn)實(shí)驗(yàn)室

東南大學(xué) 生物科學(xué)與醫(yī)學(xué)工程學(xué)院

江蘇省原子醫(yī)學(xué)研究所 影像實(shí)驗(yàn)室

湖南肯基儀器有限公司